Hepatocellular carcinoma is the most common form of liver cancer, accounting for about 90% of cases. The rising statistics of this cancer clearly highlight the importance of better understanding the mechanisms of pathogenesis and identifying new therapeutic targets. Nowadays, iron-dependent programmed cell death (ferroptosis) has extended significant attention. Long non-coding RNAs (lncRNAs), key regulators of ferroptosis, play critical roles in various cellular processes, including pathways involved in carcinogenesis, by modulating the expression of downstream genes. In the present study, by analysis the bioinformatics data recorded in the GEO database related to RNA-seq analysis, we investigated the differentially expressed genes resulting from the suppression of LncRNA SLC7A11 in the human hepatocellular carcinoma (HepG2) cell line. The results indicated that the main differentially expressed genes in this study were involved in the ferroptosis mechanisms, contributing to cancer progression. Consequently, this LncRNA could be considered an important therapeutic target for future laboratory investigation.