نوع مقاله : مقاله پژوهشی
موضوعات
عنوان مقاله English
نویسندگان English
Menopause and oophorectomy, characterized by reduced estrogen levels, lead to various physical and psychological changes, including an increased risk of depression. The gut-brain axis plays a pivotal role in regulating mood and mental behaviors, with gut microbiota being a key factor in this process. This study aimed to evaluate the effect of Bifidobacterium bifidum probiotic on depression-related behaviors in oophorectomized animal models. In this experiment, 30 female Wistar rats were divided into three groups: surgical control, oophorectomized receiving phosphate-buffered saline (PBS), and oophorectomized receiving Bifidobacterium bifidum. After oophorectomy, the rats were administered either the probiotic or PBS for 5 weeks. Depression-related behaviors were assessed using the forced swim test. The results showed that the PBS group spent significantly more time in immobility, while the probiotic group demonstrated a marked reduction in immobility time, suggesting improvement in depressive behaviors. These findings indicate that Bifidobacterium bifidum may exert protective effects against estrogen-deficiency-induced depression through the gut-brain axis.
کلیدواژهها English
